Natasha Henstridge
Lt. Melanie Ballard
Ice Cube
James 'Desolation' Williams
Pam Grier
Commander Helena Braddock
Jason Statham
Sgt. Jericho Butler
Clea DuVall
Bashira Kincaid
Joanna Cassidy
Dr. Arlene Whitlock
Richard Cetrone
Big Daddy Mars
Rosemary Forsyth
Inquisitor
Liam Waite
Michael Descanso
Peter Jason
Engineer McSimms
Michael Krawic
Man in the Rover
Eileen Weisinger
Woman Warrior
Marjean Holden
Young Woman
Charlotte Cornwell
Narrator (voice)
Danielle Burgio
Local Lady Cop (uncredited)
Lena Milan
Hand-Double (uncredited)
Damon Caro
Shape-Male Intern (uncredited)
Christopher Allen Nelson
Demon Miner (uncredited)