Michael J. Fox
Stuart Little (voice)
Chazz Palminteri
Smokey (voice)
Nathan Lane
Snowbell (voice)
Jonathan Lipnicki
George Little
David Alan Grier
Red (voice)
Jim Doughan
Lucky / Officer Allen (voice)
Bruno Kirby
Mr. Stout (voice)
Jennifer Tilly
Mrs. Stout (voice)
Stan Freberg
Race Announcer (voice)
Jeffrey Jones
Uncle Crenshaw
Allyce Beasley
Aunt Beatrice
Brian Doyle-Murray
Cousin Edgar
Estelle Getty
Grandma Estelle
Harold Gould
Grandpa Spencer
Patrick Thomas O'Brien
Uncle Stretch
Dabney Coleman
Dr. Beechwood
Jon Polito
Officer Sherman
Kimmy Robertson
Race Spectator
Tannis Benedict
Hot Dog Vendor
Westleigh M. Styer
Skipper
Larry Goodhue
Boat Registrar
Joshua Paule
New Yorker (uncredited)