Lea Thompson
Beverly Switzler
Jeffrey Jones
Dr. Walter Jenning
Tim Robbins
Phil Blumburtt
Chip Zien
Howard T. Duck (voice)
Steve Sleap
Howard T. Duck
Peter Baird
Howard T. Duck
Jordan Prentice
Howard T. Duck
Paul Guilfoyle
Lieutenant Welker
Tommy Swerdlow
Ginger Moss
Richard McGonagle
First Cop
Debbie Lee Carrington
Additional Ducks (voice)
Miguel Sandoval
Club Owner
Sheldon Feldner
Hot Tub Spa Owner
James Lashly
State Trooper
David Paymer
Larry, Scientist
Martin Ganapoler
First Trucker
Tom Rayhall
Second Trucker
Gary Littlejohn
Third Trucker
Thomas Dolby
Bartender in Rock Club
Anne Tofflemire
Lover Girl
Monty Hoffman
Club Bouncer
James Brady
First Tour Guide
Carol McElheney
Screaming Woman
Richard Kiley
The Cosmos (voice)
Mel Blanc
Daffy Duck (voice) (archive sound)