Brendan Fraser
DJ Drake / Tasmanian Devil (voice) / She-Devil (voice) / Self
Joe Alaskey
Bugs Bunny-Daffy Duck / Beaky Buzzard / Sylvester / Mama Bear (voice)
Jeff Bennett
Yosemite Sam / Foghorn Leghorn / Nasty Canasta (voice)
Timothy Dalton
Damien Drake
Billy West
Elmer Fudd / Peter Lorre (voice)
Heather Locklear
Dusty Tails
Dan Stanton
Mr. Warner's Brother
Dick Miller
Security Guard
Roger Corman
Hollywood Director
Kevin McCarthy
Dr. Bennell
Mary Woronov
Acme VP, Bad Ideas
Marc Lawrence
Acme VP, Stating the Obvious
Bill McKinney
Acme VP, Nitpicking
George Murdock
Acme VP, Unfairly Promoted
Robert Picardo
Acme VP, Rhetorical Questions
Ron Perlman
Acme VP, Never Learning
Vernon Wells
Acme VP, Child Labor
Leo Rossi
Acme VP, Climbing to the Top
Archie Hahn
Stunt Director
Austyn Cuccia
Tour Bus Girl
Marie-Claude Jacques
Flower Vendor
Michael Azria
Paris Cafe Waiter
Dan Romanelli
Studio Executive
Ryan O'Dell
Bugs Bunny Driver
Kevin Thompson
Dancing Yosemite Sam
Arturo Gil
Dancing Yosemite Sam
Gabriel Pimentel
Dancing Yosemite Sam
Steve Babiar
Dancing Yosemite Sam
Martin Klebba
Dancing Yosemite Sam
Eric Goldberg
Tweety Bird / Marvin the Martian / Speedy Gonzalez (voice)
Bruce Lanoil
Pepe le Pew (voice)
Bob Bergen
Porky Pig (voice)
Casey Kasem
Shaggy (voice)
Frank Welker
Scooby-Doo (voice)
Danny Chambers
Cottontail Smith (voice)
Stan Freberg
Baby Bear (voice)
Will Ryan
Papa Bear (voice)
Danny Mann
Robo Dog - Spy Car (voice)
Mel Blanc
Gremlin Car (archive sound)
Brenda Mae Hamilton
Dancer
John Munro Cameron
The Man from Planet X
Peter Graves
Host of Civil Defense Film
Glen Hambly
Laboratory Scientist
Michael Jordan
Self (archive footage)
Nikki Martin
Wooden Nickel Waitress
Laura Orrico
Secret Agent Shopper
Robert Parigi
Robby the Robot
Dean Ricca
Studio Tour Guide
Tom Woodruff Jr.
The Metaluna Mutant (uncredited)