Eddie Murphy
Dr. John Dolittle
Kristen Wilson
Lisa Dolittle
Raven-Symoné
Charisse Dolittle
Andy Richter
Eugene Wilson
Elayn J. Taylor
Eldon's Wife
Kevin Pollak
Riley / Alligator
Victor Raider-Wexler
Judge B. Duff
Mark Griffin
Logger / Nature Show Narrator
Ken Hudson Campbell
Animal Control Officer / Dog / Animal Groupie #3 / Forest Animal (voice)
Googy Gress
Bear Announcer
Lisa Marie Hugueley
Shamu Trainer
Steve Irwin
The Crocodile Hunter
Doug Seus
Klondike Dave Delivery Man
Brie Hill Arbaugh
Chihuahua Lady
E.J. Wessel
Guy Throwing Frisbee
Jacob Vargas
Pepito (voice)
Michael Rapaport
Joey the Raccoon (Voice)
Isaac Hayes
Possum (voice)
Andy Dick
Lennie the Weasel (voice)
Joey Lauren Adams
Squirrel (voice)
Melique Berger
Fish (voice)
David Cross
Dog / Animal Groupie #2 (voice)
David DeLuise
School Fish #2 (voice)
Trevor Denman
Horse Race Announcer (voice)
John DiMaggio
Seeing Eye Dog / Wassup Fish / Mouse (voice)
Georgia Engel
Giraffe (voice)
Jamie Kennedy
Bandit / Forest Animal / Animal Groupie #1 (voice)
Tom Kenny
Male Tortoise (voice)
Cedric the Entertainer
Zoo Bear #1 (voice)
David L. Lander
Bird (voice)
Michael McKean
Bird (voice)
Tara Mercurio
Deer (voice)
Frankie Muniz
Boy Bear Cub (voice)
Bob Odenkirk
Animal Groupie #4 / Forest Animal / Dog (voice)
Phil Proctor
Drunk Monkey (voice)
Reni Santoni
Rat #2 (voice)
Richard C. Sarafian
God Beaver (voice)
Hal Sparks
School Fish #1 (voice)
Renée Taylor
Female Tortoise (voice)
John Witherspoon
Zoo Bear #2 (voice)
Jodi Essex
Frisbee Thrower in Park (uncredited)
Lawrence Pressman
Governor of California (uncredited)
Norm Macdonald
Lucky (voice)
Crystal the Monkey
Drunk Monkey (uncredited)
Bart the Bear II
Boy Bear Cub
Arnold Schwarzenegger
White Wolf (voice) (archive sound) (uncredited)
John Leguizamo
Rat #2 (voice, uncredited)