Ron Perlman
Brother Samuel
Thomas Jane
Maj. 'Mitch' Hunter
Devon Aoki
Cpl. Valerie Duval
Sean Pertwee
Capt. Nathan Rooker
Benno Fürmann
Lt. Maximillian von Steiner
John Malkovich
Constantine
Steve Toussaint
Capt. John McGuire
Luis Echegaray
Cpl. Jesus 'El Jesus' de Barrera
Roger Ashton-Griffiths
Science Monk
Jacqueline Chan
Mishima Ambassador (as Jacqui Chan)
Tim Daniel Clark
Lead Mutant
Barry McCormick
Capitol Ambassador
Scott Joseph
Corporate Guard
Farhan Khan
Principal Mutant
Andrew Mackay
Science Monk's Assistant
Tatiana Lavrentieva
Refugee (uncredited)
Albert Tang
Japanese General (uncredited)
Pras Michel
Captain Michaels