Steve Whitmire
Kermit the Frog / Rizzo the Rat / Beaker / Elvises (voice)
Dave Goelz
The Great Gonzo / Dr. Bunsen Honeydew / Waldorf / Zoot (voice)
Bill Barretta
Pepe the King Prawn / Bobo the Bear / Johnny Fiama / Swedish Chef / Lew Zealand / Howard Tubman / Rowlf the Dog / Elvises (voice)
Eric Jacobson
Miss Piggy / Fozzie Bear / Animal / Yoda / Elvises (voice)
Joan Cusack
Rachel Bitterman
Matthew Lillard
Luc Fromage
Whoopi Goldberg
Daniel's 'Boss'
Robert Smigel
Triumph, the Insult Comic Dog (voice)
Zach Braff
Dr. John "J.D." Dorian
Sarah Chalke
Dr. Elliot Reid
John C. McGinley
Dr. Perry Cox
Judy Reyes
Nurse Carla Espinosa
Mel Brooks
Joe Snow (voice)
Dave 'Squatch' Ward
Sally Ann Santa Claus
Brian Henson
Scooter / Janice / Sal Minella (voice)
Kevin Clash
Sam Eagle (voice)
John Henson
Sweetums (voice)
Jerry Nelson
Robin the Frog / Statler / Announcer / Pops / Floyd Pepper
John E. Kennedy
Dr. Teeth (voice)
Allan Trautman
Eugene the Tuba Player (voice)
Alice Dinnean
Additional Muppet Performer (voice)
Geoff Redknap
Additional Muppet Performer (voice)/ Sweetums
Denise Cheshire
Additional Muppet Performer (voice)
Drew Massey
Additional Muppet Performer (voice)
Adam Behr
Additional Muppet Performer (voice)
Gord Robertson
Additional Muppet Performer (voice)
Dawn Lewis
Fear Factor Contestant
Marci Dacus
Fear Factor Contestant (uncredited)
Cameron McDonald
Safari Animal Tracker
Darrell Lee-Izeard
Thin Angel
Chantal Strand
Nancy Nut-What
Robin Mossley
Nicki Nut-What
Dan Payne
Handsome Executive
Julia Arkos
Sally Ann Representative
