Antonio Banderas
El Mariachi
Johnny Depp
CIA Agent Jeffrey Sands
Salma Hayek Pinault
Carolina
Mickey Rourke
Billy Chambers
Willem Dafoe
Armando Barillo
Eva Mendes
CIA Agent Ajedrez
Rubén Blades
Jorge, Retired FBI Agent
Gerardo Vigil
General Marquez
Pedro Armendáriz Jr.
President of Mexico
Julio Oscar Mechoso
Nicholas, Presidential Advisor
Miguel Couturier
Dr. Guevera
Natália Torres
El Mariachi's Daughter
Steve Constancio
Right Hand
Carola Vázquez
Hospital Administrator
René Gatica
Chief Federale
Silvia Santoyo
Bachelorette
Juan Pablo Llaguno
Bull Fighter
Víctor Carpinteiro
Left Nut
Thomas Rosales Jr.
Bartender with Gun (uncredited)
Khristian Lupo
Soldier (uncredited)