Adrien Brody
Leonard Chess
Jeffrey Wright
Muddy Waters
Gabrielle Union
Geneva Wade
Columbus Short
Little Walter
Cedric the Entertainer
Willie Dixon
Emmanuelle Chriqui
Revetta Chess
Eamonn Walker
Howlin' Wolf
Tammy Blanchard
Isabelle Allen
Norman Reedus
Chess Engineer
Tim Bellow
Man in the Caddy
Douglas Crosby
Policeman (Little Walter beating)
Dexter Darden
Geneva's Teenage Son
Sean Shyboy Davis
Toothless Hillbilly Little Walter
Eshaya Draper
Charles Waters
Christopher Durham
Policeman (with Chuck Berry)
Shiloh Fernandez
Phil Chess
Erik Frandsen
Engineer - Present Day
Suzette Gunn
Minnie Ripperton
William Hill
Policeman (with the Stones)
Tyler Humphrey
Muddy - Age 6
Kevin Jackson
Mysterious Black Man
Albert Jones
Hubert Sumlin
Rayan Lawrence
Harmonica Player
Chyna Layne
Pot's Girlfriend Juanita
Rebecca Pappa
Another Blonde
Jonathan Earl Peck
Man Who Rolled 7
Ginnie Randall
Muddy's Grandmother
Ashlee Ray
Muddy's Floozy #1
Jake Robards
Producer - Present Day
Valence Thomas
James Cotton
Carmen Ziina Vasquez
Muddy's Floozy #2
Isiah Whitlock Jr.
Mississippi DJ
Kade Alexie
Guitar Player (uncredited)
Kandé Amadou
Little Walter's Girlfriend (uncredited)
Angelina Aucello
Teenybopper (uncredited)
Lawrence P. Beron
Overseer (uncredited)
Ryan Curtis
Picnic Boyfriend (uncredited)
Vincent D'Onofrio
Mississippi DJ (uncredited)
Seth Donavan
Chuck Berry Concertgoer (uncredited)
John Farrer
Etta's Violinist (uncredited)
Doug W. Goldman
Etta's Trumpet Player (uncredited)
Evan Hart
Young Lover (uncredited)
Tiffany M. Johnson
Girlfriend (uncredited)
Vianca Johnson
Field Worker (uncredited)
Andrew Kaempfer
Chicago Cop (uncredited)
Tony Lawson
Vendor (uncredited)
Rege Lewis
Bystander (uncredited)
Malikha Mallette
Little Walter's Girlfriend (uncredited)
Cerrone May
Muddy's Band Member (uncredited)
Adaku Ononogbo
Muddy Waters' Girlfriend (uncredited)
Catherine Pierce
Shocked Bystander (uncredited)
Stephen Seidel
Officer Brown (uncredited)
Derrick Simmons
Dice Player (uncredited)