Brandon Routh
Clark Kent / Superman
James Marsden
Richard White
Parker Posey
Kitty Kowalski
Frank Langella
Perry White
Sam Huntington
Jimmy Olsen
Eva Marie Saint
Martha Kent
Tristan Lake Leabu
Jason White
Jack Larson
Bo the Bartender
Noel Neill
Gertrude Vanderworth
Keegan Joyce
Boy with Camera
Jordana Beatty
Little Girl
Stephan Bender
15 Year Old Clark
Ian Bliss
Shuttle Commander
Ansuya Nathan
Shuttle Pilot
Richard Branson
Shuttle Engineer
Warwick Young
777 Co-Pilot
Bradd Buckley
777 Navigator
Bill Young
Mission Control Flight Director
Karina Bracken
Hospital Ward Nurse
Raelee Hill
Hospital Nurse
Frederique Fouche
French News Anchor (as Frederique Fouché)
Rebecca Barratt
German Reporter
Karen Pang
Hospital Reporter #8
Jennifer Sciole
EMT (uncredited)
Donald MacDonald
British Scientist