Selma Blair
Elizabeth 'Liz' Sherman
Doug Jones
Abraham 'Abe' Sapien
John Hurt
Prof. Trevor 'Broom' Bruttenholm
Jeffrey Tambor
Tom Manning
Ladislav Beran
Karl Ruprecht Kroenen
Bridget Hodson
Ilsa Haupstein
Karel Roden
Grigori Rasputin
Kevin Trainor
Young 'Broom'
Stephen Fisher
Agent Quarry
Angus MacInnes
Sgt. Whitman
Richard Haas
Second Doctor
Andrea Miltner
Doctor Marsh
Jo Eastwood
Down's Patient
Charles Grisham
Museum Guard
Jeremy Zimmermann
Lobby Guard
Andrea Stuart
Girl with Kittens
William Hoyland
General Klaus Werner von Krupt
Bob Sherman
Television Host
Ellen Savaria
Blonde Television Reporter
Petr Sekanina
German Scientist
Aleš Košnar
German Scientist
Winter Ave Zoli
Girlfriend
Santiago Segura
Train Driver
David Hyde Pierce
Abe Sapien (voice) (uncredited)
Helene Maksoud
Liz Sherman's Mother (uncredited)
Guillermo del Toro
Guy Dressed as Dragon (uncredited)
Mike Mignola
Knight (uncredited)
Miroslav Lhotka
Museum Guard (uncredited)
Michael Lindsay
Security Guard (voice) (uncredited)
Todd Kramer
Radioman (uncredited)