Mitch Cohen
The Toxic Avenger
Dick Martinsen
Officer O'Clancy
David Weiss
Chief of Police
Sarabel Levinson
Melvin's Mom
Reuben Guss
Dr. Snodburger
Kenneth Kessler
Toxic Avenger's Voice (voice)
Randy Schein
Bozo's Friend
Richard Duggan
Ice Cream Man
Donna Winter
Mayor's Secretary
Marisa Tomei
Health Club Girl (uncredited)