The film revolves around a shady factory that secretly digs up graves and unearths a two-headed python. Unlike previous snake thrillers where humans actively invade the rainforest, this time, the snakes descend en masse to launch a preemptive attack on a human settlement. Security captain Li Mingjun (Wu Tingye) and his apprentice Xie Feng (Jin Long) watch the hunt from a surveillance room to lure out the two-headed python. They then collude with factory manager Zhao Yongmin (Xu Shaohang) to transport sick pigs and instruct butcher Zhang Dawen (Li Long) to trap the python with a live human. Female forklift driver Xia Qing (Yang Lei) teams up with her fellow worker Wang Siyan (Chen Xinzhe) to fight against the forces of greed, ultimately shedding a venomous venom with maternal love.