All Cast

Reese Witherspoon

Reese Witherspoon

Susan Murphy / Ginormica (voice)

Seth Rogen

Seth Rogen

B.O.B. (voice)

Hugh Laurie

Hugh Laurie

Dr. Cockroach Ph.D. (voice)

Rainn Wilson

Rainn Wilson

Gallaxhar (voice)

Will Arnett

Will Arnett

The Missing Link (voice)

Kiefer Sutherland

Kiefer Sutherland

General W.R. Monger (voice)

Paul Rudd

Paul Rudd

Derek Dietl (voice)

Stephen Colbert

Stephen Colbert

President Hathaway (voice)

Julie White

Julie White

Wendy Murphy (voice)

Jeffrey Tambor

Jeffrey Tambor

Carl Murphy (voice)

Amy Poehler

Amy Poehler

Computer (voice)

Ed Helms

Ed Helms

News Reporter (voice)

Renée Zellweger

Renée Zellweger

Katie (voice)

Sean Bishop

Sean Bishop

Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)

Rich Dietl

Rich Dietl

Commander / Advisor Smith (voice)

Rob Letterman

Rob Letterman

Secret Service Man #1 / Lieutenant (voice)

Tom McGrath

Tom McGrath

Wilson (voice)

Chris Miller

Chris Miller

Advisor Cole / Army Commander Jones (voice)

Mike Mitchell

Mike Mitchell

Advisor Wedgie (voice)

Kent Osborne

Kent Osborne

Technician Jerry (voice)

Latifa Ouaou

Latifa Ouaou

Advisor Ouaou / Mrs. Ronson / Female Advisor #2 / Panicked Guest (voice)

Geoffrey Pomeroy

Geoffrey Pomeroy

Soldier #4 / Pilot / Soldier #3 / News Technician (voice)

David P. Smith

David P. Smith

Soldier #1 / Advisor Jackson (voice)

Lisa Stewart

Lisa Stewart

Bridesmaid Candy (voice)

Conrad Vernon

Conrad Vernon

Advisor Hawk / Advisor Dither / Minister / Secret Service Man #2 / Mama Dietl (voice)

John Krasinski

John Krasinski

Cuthbert (voice)

Stephen Kearin

Stephen Kearin

Technician Bee (voice)