Basil Rathbone
Sherlock Holmes
Alan Marshal
Jerrold Hunter
George Zucco
Professor Moriarty
Henry Stephenson
Sir Ronald Ramsgate
E. E. Clive
Inspector Bristol
Arthur Hohl
Henchman Bassick
May Beatty
Mrs. Jameson, Brandon Housekeeper
Peter Willes
Lloyd Brandon
Holmes Herbert
Justice of the Court
George Regas
Henchman Mateo
Mary Forbes
Lady Conyngham
Frank Dawson
Dawes, Moriarty's servant
William Austin
Inquisitive Stranger
Anthony Kemble-Cooper
Tony Conyngham
Leonard Mudie
Barrows - Moriarty's Attorney (uncredited)
Robert Nobel
Foreman of the Jury (uncredited)
Ivan F. Simpson
Gates - Trial Prosecutor (uncredited)
Neil Fitzgerald
Clerk of the Court (uncredited)
Frank Baker
Tompkins (uncredited)
Denis Greene
Denis Green (uncredited)
Robert Cory
Tower Sentry (uncredited)
Gordon Hart
Guard (uncredited)
Keith Hitchcock
Constable (uncredited)
Ivo Henderson
Bobby (uncredited)
Leyland Hodgson
Bobby (uncredited)
Boyd Irwin
Bobby (uncredited)
Charles Irwin
Marine Sergeant (uncredited)
Robert R. Stephenson
Cabby (uncredited)
Harry Cording
Second Fake Constable (uncredited)
Eric Wilton
Conyngham Butler (uncredited)
Frank Benson
Cockney (uncredited)
Ted Billings
Pub Customer (uncredited)
Herbert Evans
Scotland Yard Man (uncredited)