Sam Rockwell
Darwin the Guinea Pig (voice)
Jon Favreau
Hurley the Guinea Pig (voice)
Tracy Morgan
Blaster the Guinea Pig (voice)
Penélope Cruz
Juarez the Guinea Pig (voice)
Nicolas Cage
Speckles the Mole (voice)
Dee Bradley Baker
Mooch the Fly (voice)
Steve Buscemi
Bucky the Hamster (voice)
Jared Lavette
Jared the Skunk (voice)
Micah Lavette
Micah the Fox (voice)
Loudon Wainwright III
Grandpa Goodman
Tyler Patrick Jones
Connor
Piper Mackenzie Harris
Penny
Corey Michael Eubanks
Agent
Mini Anden
Saber's Assistant
Camaron Engels
Skateboarder #1 (as Cameron Engels)
Jack Conley
Agent Trigstad
