Christy Carlson Romano
Kim Possible (voice)
Will Friedle
Ron Stoppable (voice)
Nancy Cartwright
Rufus (voice)
Mayim Bialik
Justine Flanner (voice)
Gary Cole
Dr. Possible (voice)
John DiMaggio
Dr. Drakken (voice)
Shaun Fleming
Jim Possible / Tim Possible (voice)
Rob Paulsen
Hank Perkins (voice)
Brian George
Duff Killigan (voice)
Tom Kane
Monkey Fist (voice)
Kerri Kenney
Additional Voices (voice)
Melissa McCarthy
Amy Hall (voice)
Jean Smart
Dr. Ann Possible (voice)
Kirsten Storms
Bonnie Rockwaller (voice)
Nicole Sullivan
Shego (voice)
Raven-Symoné
Monique (voice)
Patrick Warburton
Steve Barkin (voice)
Gedde Watanabe
Professor Bob Chen (voice)
Jo Anne Worley
Additional Voices (voice)
Frank Welker
Professor Otto Allenford (voice)
Diedrich Bader
Lars (voice; uncredited)
Eddie Deezen
Ned (voice; uncredited)
Clyde Kusatsu
Nakasumi (voice; uncredited)
Maurice LaMarche
'Big Daddy' Brotherson (voice; uncredited)
Phil LaMarr
Ninja / Japanese Businessman #2 (voice; uncredited)
Kevin Michael Richardson
Sumo Ninja / Dr. Gooberman / Businessman (voice; uncredited)
Stephen Root
Cowboy Gambler (voice; uncredited)
Rider Strong
Brick Flagg (voice; uncredited)
Tara Strong
Computer (voice; uncredited)
Lauren Tom
Yoshiko (voice; uncredited)
Ricky Ullman
Eric (voice; uncredited)
April Winchell
Reporter (voice; uncredited)