Tobin Bell
John Kramer / Jigsaw
Costas Mandylor
Mark Hoffman
Shawnee Smith
Amanda Young
Peter Outerbridge
William Easton
Athena Karkanis
Agent Perez
Samantha Lemole
Pamela Jenkins
François Sagat
Male Addict
Tenika Davis
Irate Clinic Woman
Karl Campbell
Security Guard
Jessie Rusu
Female Officer
Chris Owens
Additional Voice Talent (voice)
Vickie Papavs
Additional Voice Talent (voice)
Catherine Rix
Additional Voice Talent (voice)
John Watson
Additional Voice Talent (voice)
Joris Jarsky
Seth (uncredited)
Angus Macfadyen
Jeff Denlon (uncredited)
Scott Patterson
Agent Strahm (uncredited)
Bahar Soomekh
Lynn Denlon (uncredited)
Niamh Wilson
Corbett Denlon (uncredited)