Dan Aykroyd
Clifford Skridlow / Doctor Detroit
Howard Hesseman
Smooth Walker
T.K. Carter
Diavolo Washington
Lynn Whitfield
Thelma Cleland
Fran Drescher
Karen Blittstein
Nan Martin
Margaret Skridlow
George Furth
Arthur Skridlow
Pershing P. Anderson
Stretch
William Munchow
Professor Artel
Ed Meekin
Professor Durant
Peter Aykroyd
Mr. Frankman
Glenne Headly
Miss Debbylike
Annabel Armour
Airline Clerk
Robert Cornthwaite
Professor Blount
Thomas O. Erhart Jr.
Dean Swift
Oliver Clark
Shaky Alcoholic Lawyer
Andrew Duggan
Harmon Rousehorn
Victoria Brown
Mrs. Fulsom
Blackie Dammett
Eddie Four Eyes
Marilyn Corwin
Dancer (uncredited)