Sid Haig
Captain Spaulding
Bill Moseley
Otis B. Driftwood
Sheri Moon Zombie
Baby Firefly
Karen Black
Mother Firefly
Erin Daniels
Denise Willis
Chris Hardwick
Jerry Goldsmith
Jennifer Jostyn
Mary Knowles
Tom Towles
Lieutenant George Wydell
Walton Goggins
Deputy Steve Naish
Matthew McGrory
Tiny Firefly
Robert Allen Mukes
Rufus 'RJ' Firefly Jr.
Dennis Fimple
Grandpa Hugo Firefly
Jake McKinnon
Rufus 'Earl' Firefly Sr.
William Bassett
Sheriff Frank Huston
David Reynolds
Richard 'Little Dick' Wick
Judith Drake
Skunk Ape Wife
Gregg Gibbs
Dr. Wolfenstein
Ken Johnson
Skunk Ape Husband
Irvin Mosley Jr.
Lewis Dover
Rob Zombie
Dr. Wolfenstein's assistant (uncredited)