Alec Baldwin
Theodore Templeton (voice)
Steve Buscemi
Francis E. Francis (voice)
Miles Bakshi
Tim Templeton (voice)
Jimmy Kimmel
Ted Templeton (voice)
Lisa Kudrow
Janice Templeton (voice)
Tobey Maguire
Narrator / Older Tim Templeton (voice)
Conrad Vernon
Eugene Francis (voice)
James McGrath
Wizzie / Elvis Impersonator (voice)
Nina Zoe Bakshi
Tim's Daughter / Girl / Little Girl (voice)
Tom McGrath
TV Chef (voice)
Walt Dohrn
Photographer (voice)
James Ryan
Story Bear (voice)
Eric Bell Jr.
Triplets (voice)
Edie Mirman
Big Boss Baby (voice)
James Izzo
Elvis impersonator (voice)
Chris Miller
Captain Ross (voice)
Chloe Albrecht
Hazmat Baby (voice)
Andrea Montana Knoll
Flight Attendant (voice)
Joseph Izzo
Elvis Impersonators (voice)
Glenn Harmon
Airport Announcer (voice)
Brian Hopkins
Airport Security Guard (voice)
Jules Winter
Crying Boy / Little Boy / Boy (voice)