Tom Cruise
Frank T.J. Mackey
Philip Baker Hall
Jimmy Gator
Philip Seymour Hoffman
Phil Parma
Julianne Moore
Linda Partridge
William H. Macy
Quiz Kid Donnie Smith
John C. Reilly
Officer Jim Kurring
Melora Walters
Claudia Wilson Gator
Jeremy Blackman
Stanley Spector
Jason Robards
Earl Partridge
Michael Bowen
Rick Spector
Ricky Jay
Burt Ramsey / Narrator
Pat Healy
Sir Edmund William Godfrey / Young Pharmacy Kid
Genevieve Zweig
Mrs. Godfrey
Mark Flanagan
Joseph Green
Patton Oswalt
Delmer Darion
Raymond 'Big Guy' Gonzales
Reno Security Guard
Jim Meskimen
Forensic Scientist
Chris O'Hara
Sydney Barringer
Clement Blake
Arthur Barringer
Frank Elmore
1958 Detective
John Kraft Seitz
1958 Policeman
Tim Soronen
Infomercial Guy
Jim Ortlieb
Middle-Aged Guy
Thomas Jane
Young Jimmy Gator
Holly Houston
Jimmy's Showgirl
Benjamin Niedens
Little Donnie Smith
Veronica Hart
Dentist Nurse #1
Missy Spell Tanner
Dentist Nurse #2
James Kiriyama-Lem
Dr. Lee
Charlie Scott Jr.
Pedestrian #2
John Pritchett
Police Captain
Michael Shamus Wiles
Captain Muffy
Kevin Breznahan
Geoff, Seminar Guy
Alfred Molina
Solomon Solomon
Lionel Mark Smith
Detective
Annette Helde
Coroner Woman
Scott Burkett
WDKK Page #1
Julie Brewer
Richard's Mom
Maurey Marston
Julia's Dad
Patrick Warren
Todd Geronimo
Virginia Pereira
Pink Dot Girl (voice)
Craig Kvinsland
Brad the Bartender
Patricia Scanlon
Cocktail Waitress
Henry Gibson
Thurston Howell
Natalie Elizabeth Marston
Julia
Clark Gregg
WDKK Floor Director
Art Frankel
Old Pharmacist
Guillermo Melgarejo
Pink Dot Guy
Paul F. Tompkins
Chad (Seduce & Destroy) (voice)
Mary Lynn Rajskub
Janet (Frank's Assistant) (voice)
Jim Beaver
Smiling Peanut Patron #1
Ezra Buzzington
Smiling Peanut Patron #2
Denise Woolfork
Smiling Peanut Patron #3
Michael Murphy
Alan Kligman, Esq.
Robert Downey Sr.
WDKK Show Director
William Mapother
WDKK Show Director's Assistant
Brett Higgins
Mackey Disciple Twin #1
Brian Higgins
Mackey Disciple Twin #2
Michael Lee Phillips Jr.
Mackey Disciple in Middle
Lillian Adams
Donnie's Old Neighbor
Scott Alan Smith
E.R. Doctor
Paul Thomas Anderson
Man Confiscating Sign (uncredited)
Miriam Margolyes
Faye Barringer (uncredited)
Bruno Angelico
Fireman #2 (uncredited)
Robert Bella
Detective #2 (uncredited)
Greg Bronson
Waiter (uncredited)
Douglas Busby
Extra (uncredited)
Marc Davies
Seminar Attendee #1 (uncredited)
Bruce Gregory
Randy (uncredited)
Phil Hawn
Bob (uncredited)
Spencer Kayden
Seminar Patron (uncredited)
Brian Kehew
Seminar Patron (uncredited)
Michael Laren
Officer Tom 1958 (uncredited)
Aimee Mann
Hot Date Infomercial (uncredited)
Tom Ohmer
Detective (uncredited)
Colleen Pelletier
Gameshow Audience Member (uncredited)
Herb Santos Jr.
21 Dealer (uncredited)
Tom Tangen
Drunken Dart Player (uncredited)