Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. John Watson
Hillary Brooke
Lydia Marlowe
Henry Daniell
Professor James Moriarty
Paul Cavanagh
Sir George Fenwick
Matthew Boulton
Inspector Gregson
Frederick Worlock
Dr. Onslow
Percival Vivian
Dr. Simnell
Coulter Irwin
Corporal Williams
John Burton
Waring the Mesmerist (uncredited)
Harold De Becker
Shoelace Vendor Henchman (uncredited)
Tony Ellis
Carter the Hypnotized Subject (uncredited)
Bess Flowers
Bar Patron (seen in mirror) (uncredited)
Kay Harding
4th Victim (uncredited)
Alec Harford
Commissioner of the CID (uncredited)
Olaf Hytten
Fenwick's Butler Norris (uncredited)
Boyd Irwin
Short-Tempered Officer Closing Window (uncredited)
Eric Mayne
Member of Mesmer Club (uncredited)
William H. O'Brien
Pembrook House Waiter (uncredited)