Wesley Snipes
Eric Brooks / Blade
Jessica Biel
Abigail Whistler
Ryan Reynolds
Hannibal King
Kris Kristofferson
Abraham Whistler
Dominic Purcell
Dracula / Drake
Natasha Lyonne
Sommerfield
James Remar
Ray Cumberland
John Michael Higgins
Dr. Edgar Vance
Callum Keith Rennie
Asher Talos
Paul Lévesque
Jarko Grimwood
Mark Berry
Chief Martin Vreede
Michael Anthony Rawlins
Wilson Hale
Eric Bogosian
Bentley Tittle
Erica Cerra
Goth Vixen Wannabe
Shannon Powell
Woman Bystander
Brian Steele
Drake Creature (uncredited)
Christopher Heyerdahl
Caulder
