Will Forte
Shaggy Rogers (voice)
Frank Welker
Scooby-Doo / Pterodactyl (voice)
Mark Wahlberg
Blue Falcon (voice)
Jason Isaacs
Dick Dastardly (voice)
Ken Jeong
Dynomutt, Dog Wonder (voice)
Amanda Seyfried
Daphne Blake (voice)
Gina Rodriguez
Velma Dinkley (voice)
Zac Efron
Fred Jones (voice)
Iain Armitage
Young Shaggy (voice)
Ariana Greenblatt
Young Velma (voice)
Mckenna Grace
Young Daphne (voice)
Pierce Gagnon
Young Fred (voice)
Kiersey Clemons
Dee Dee Skyes (voice)
Tracy Morgan
Captain Caveman (voice)
Simon Cowell
Simon Cowell (voice)
Harry Perry
Harry Perry (voice)
Kevin Heffernan
Bike Cop Gary (voice)
Christina Hendricks
Officer Jaffe (voice)
Henry Winkler
Keith (voice)
John DiMaggio
Restaurant Owner (voice)
Ira Glass
Ira Glass (voice)
Henry Kaufman
Chad / Chet (voice)
Maya Erskine
Judy Takamoto (voice)
Billy West
Muttley (voice)
Don Messick
Muttley (archive sound) (voice)
Fred Tatasciore
Cerberus (voice)
Kennedy Peil
Indira Knight (voice)
John McDaniel
Hal Murphy (voice)
Ryan Folsey
Beach Guy (voice)
Justina Machado
Jamie Rivera (voice)
Pam Coats
Mrs. Rogers (voice)
Tony Cervone
Ghost / Mr. Rigby / Alice (voice)
Alex Kauffman
Officer North (voice)
Vanara Taing
Baby Rotten (voice)
Sarah Lancia
Dispatcher Stevens (voice)
Adam Sztykiel
Officer Casey (voice)
Michael Kurinsky
Samuel Colton (voice)