Ryan Reynolds
Detective Pikachu (voice)
Kathryn Newton
Lucy Stevens
Suki Waterhouse
Ms. Norman
Chris Geere
Roger Clifford
Ken Watanabe
Lieutenant Hide Yoshida
Bill Nighy
Howard Clifford
Alejandro De Mesa
Bartender
Max Fincham
Young Tim Goodman
Ryoma Takeuchi
Male Pokémon Trainer
Rina Hoshino
Mewtwo (voice)
Kotaro Watanabe
Mewtwo (voice)
Ikue Otani
Pikachu (voice)