Philip Seymour Hoffman
Caden Cotard
Jennifer Jason Leigh
Maria
Michelle Williams
Claire Keen
Catherine Keener
Adele Lack
Tom Noonan
Sammy Barnathan
Sadie Goldstein
Olive (4 years old)
Hope Davis
Madeleine Gravis
Dianne Wiest
Ellen Bascomb / Millicent Weems
Stanley Krajewski
Actor as Caden
Kristen Bush
Actress Playing Claire
Alice Drummond
Actress Playing Frances
Amy Wright
Burning House Realtor
Deirdre O'Connell
Ellen's Mother
Elizabeth Marvel
Warehouse Realtor
Charles Techman
Like Clockwork Patient
Jerry Adler
Caden's Father
Peter Friedman
Emergency Room Doctor
Stephen Adly Guirgis
Davis
Christopher Evan Welch
Pastor
Tim Guinee
Needleman Actor
Michael Higgins
Actor Playing Man with Nose Bleed
Barbara Haas
Warehouse Actress
Greg McFadden
Actor Playing Needleman Actor
Alvin Epstein
Man with Nose Bleed
Gerald Emerick
Man in Line
Chris McGinn
Lady at Caden's Mom's
Dan Ziskie
Leg Tremor Doctor
Portia
Therapy Patient Actress
Nicholas Wyman
Soap Actor Doctor
Amy Spanger
Soap Actress Nurse
Raymond Angelic Sr.
German Doctor
Frank Wood
Evaluative Services Doctor
Amanda R. Phillips
Emergency Room Nurse
Kat Peters
Ellen (10 years old)