Christy Carlson Romano
Kim Possible (voice)
Will Friedle
Ron Stoppable (voice)
Nancy Cartwright
Rufus (voice)
Gary Cole
Dr. Possible (Dad) (voice)
John DiMaggio
Dr. Drakken (voice)
Michael Dorn
Rufus 3000 (voice)
Michael Clarke Duncan
Future Wade (voice)
Dakota Fanning
Preschool Kim Possible (voice)
Vivica A. Fox
Future Monique (voice)
Elliott Gould
Mr. Stoppable (voice)
Nicole Sullivan
Shego (voice)
Kirsten Storms
Bonnie Rockwaller (voice)
Jean Smart
Dr. Ann Possible (voice)
Raven-Symoné
Monique (voice)
Harrison Fahn
Preschool Ron (voice)
Tom Kane
Monkey Fist (voice)
Brian George
Duff Killigan (voice)
Shaun Fleming
Jim and Tim Possible (voice)
Freddie Prinze Jr.
Future Jim and Tim Possible (voice)
Kelly Ripa
Future Bonnie Rockwaller (voice)
Frank Welker
Animal Vocal Effects (uncredited) (voice)