Reese Witherspoon
Susan Murphy / Ginormica (voice)
Hugh Laurie
Dr. Cockroach Ph.D. (voice)
Will Arnett
The Missing Link (voice)
Kiefer Sutherland
General W.R. Monger (voice)
Rainn Wilson
Wicked Jack (voice)
Jeffrey Tambor
Carl Murphy (voice)
Julie White
Wendy Murphy (voice)
Rich Dietl
B.O.B. Kid / Husband / Pumpkins (voice)
Walt Dohrn
Link Kid (voice)
Susan Fitzer
Little Girl (voice)
Ava Kelly
Cat Girl (voice)
Andrea Montana Knoll
Mom (voice)
Latifa Ouaou
Boy / Old Lady (voice)
Peter Ramsey
Dad / Farmer Jeb (voice)
Conrad Vernon
Man on Cell / Woman (voice)
