Tobey Maguire
Spider-Man / Peter Parker
Willem Dafoe
Green Goblin / Norman Osborn
Kirsten Dunst
Mary Jane Watson
Cliff Robertson
Ben Parker
Rosemary Harris
May Parker
J.K. Simmons
J. Jonah Jameson
Joe Manganiello
Flash Thompson
Gerry Becker
Maximilian Fargas
Bill Nunn
Joseph 'Robbie' Robertson
Stanley Anderson
General Slocum
Ron Perkins
Dr. Mendel Stromm
Michael Papajohn
Carjacker
Bruce Campbell
Ring Announcer
Elizabeth Banks
Miss Brant
Taylor Gilbert
Madeline Watson
Randy Poffo
Bone Saw McGraw
Larry Joshua
Wrestling Promoter
Timothy Patrick Quill
Wrestling Arena Guard
Kristen Davidson
Bone-ette
Jason Padgett
Flash's Crony
Jim Ward
Project Coordinator
Octavia Spencer
Check-In Girl
Shane Habberstad
Little Billy
Deborah Wakeham
Billy's Mom
Rachael Bruce
Times Square Child
Mackenzie Bryce
Times Square Child
Julia Barrie
Times Square Child
Sylva Kelegian
Mother at Fire
Kristen Marie Holly
Young Lady at Fire
Matt Smith
Cop at Carjacking
Sara Ramirez
Cop at Carjacking
Lucy Lawless
Punk Rock Girl
Jayce Bartok
Subway Guitarist
Maribel González
Lady Dogwalker
Joseph D'Onofrio
Opinionated Cop
Jim Norton
Surly Truck Driver
Corey Mendell Parker
Chaperone in Tram
William Joseph Firth
Boy in Tram
Laura Gray
Tram Group Mother
Joe Virzi
New Yorker on Bridge
Michael Edward Thomas
New Yorker on Bridge
Jeanie Fox
New Yorker on Bridge
Robert Kerman
Tugboat Captain
Stan Lee
Man in Fair (uncredited)
Una Damon
Lab Tour Guide (uncredited)
Rick Avery
Cop (uncredited)
Peter Aylward
Colonel (uncredited)
Jillian Clare
Crying Girl in Tram (uncredited)
Chris Coppola
Kyle (uncredited)
Jesse Heiman
Spectator at School Fight (uncredited)
Leroy Patterson
World Unity Festival Attendant (uncredited)
Benny Urquidez
Mugger (uncredited)
Scott L. Schwartz
Screaming Wrestler (uncredited)
Jophery C. Brown
Chef (uncredited)
Brian J. Williams
Young Thug #2 (uncredited)
Mark De Alessandro
Cop (uncredited)
Tia Dionne Hodge
Uptown Woman (uncredited)
Loren Janes
Board of Directors Member (uncredited)
Andray Johnson
Balkan's Aide (uncredited)
Martin Pfefferkorn
Thug on 8x10 (uncredited)
Tammi Sutton
Street Vendor (uncredited)
Lindsay Thompson
Mary Jane's Friend (uncredited)
Sean Valla
Boat Light Man (uncredited)
Pete Macnamara
Pentagon Officer (uncredited)
Joni Avery
Cop (uncredited)
Sam Raimi
Popcorn Thrower (uncredited)
Craig "Radioman" Castaldo
Man with Bike (uncredited)