Ellen Burstyn
Sara Goldfarb
Jennifer Connelly
Marion Silver
Marlon Wayans
Tyrone C. Love
Christopher McDonald
Tappy Tibbons
Suzanne Shepherd
Mrs. Scarlini
Charlotte Aronofsky
Mrs. Miles
Mark Margolis
Mr. Rabinowitz
Michael Kaycheck
Donut Cop
Jack O'Connell
Corn Dog Stand Boss
Sean Gullette
Arnold the Shrink
Abraham Abraham
King Neptune
Te'ron A. O'Neal
Young Tyrone
Denise Dowse
Tyrone's Mother
Eddie De Harp
Brody's Henchman Victor
Scott Franklin
Jailer (voice)
Peter Cheyenne
Sal the Geep
Abraham Aronofsky
Newspaper Man on Train
James Chinlund
Space Oddity
Olga Merediz
Malin & Block Secretary
Allison Furman
Malin & Block Office Woman
Robert Dylan Cohen
Paramedic Greenhill
Dylan Baker
Southern Doctor
Shaun O'Hagan
Ward Attendant Seto
Leland Gantt
Ward Attendant Penn
Jimmie Ray Weeks
Prison Guard
Henry Stram
ECT Technician
Heather Litteer
Big Tim Party Girl
Jenny Decker
Big Tim Party Girl
Ami Goodheart
Big Tim Party Girl
Nina Zavarin
Big Tim Party Girl
Stanley B. Herman
Uncle Hank
Jim Centofanti
Party Animal
Daniel Clarin
Party Animal
Brett Feinstein
Party Animal
Andrew Kessler
Party Animal
Ross Lombardo
Party Animal
Carter Mansbach
Party Animal
Joshua Pollack
Party Animal
Geordan Reisner
Party Animal
Keith Scandore
Party Animal
David Seltzer
Party Animal
Chris Varvaro
Party Animal
Ricardo Viñas
Party Animal
Jesse Weissberger
Party Animal
Greg Weissman
Party Animal
Hubert Selby Jr.
Laughing Guard
Darren Aronofsky
Visitor (uncredited)